Lifespan Considerations<\/h1>\r\nNeonate & Pediatric:<\/strong> The developing liver in infants and young children produces decreased levels of microsomal enzymes. This may result in a decreased ability of the young child or neonate to metabolize medications. In contrast, older children may experience increased metabolism and require higher doses of medications once the hepatic enzymes are fully produced.[footnote]Fernandez, E., Perez, R., Hernandez, A., Tejada, P., Arteta, M., & Ramos, J. T. (2011). Factors and mechanisms for pharmacokinetic differences between pediatric population and adults. Pharmaceutics, 3(1), 53\u201372. https:\/\/doi.org\/10.3390\/pharmaceutics3010053<\/a>[\/footnote]\r\n\r\nOlder Adult:<\/strong> Hepatic metabolism may experience a significant decline in the older adult. As a result, dosages should be adjusted according to the client's liver function and anticipated metabolic rate. First-pass metabolism is also decreased with aging; therefore, older adults may have higher \"free\" circulating drug concentrations and be at higher risk for side effects and toxicities.[footnote]Fernandez, E., Perez, R., Hernandez, A., Tejada, P., Arteta, M., & Ramos, J. T. (2011). Factors and mechanisms for pharmacokinetic differences between pediatric population and adults. Pharmaceutics, 3(1), 53\u201372. https:\/\/doi.org\/10.3390\/pharmaceutics3010053<\/a>[\/footnote]\r\n\r\nClinical Reasoning and Decision Making Activity 1.5<\/p>\r\n\r\n<\/header>\r\n
\r\n\r\n![\"Image](\"https:\/\/opentextbc.ca\/accessibilitytoolkit\/wp-content\/uploads\/sites\/397\/2022\/05\/ORN-Icons_internet-copy_internet-copy-300x300-1.png\")
Metabolism can be influenced by many factors within the body. If a client has liver damage, the client may not be able to break down (metabolize) medications as efficiently. Dosages are calculated according to the liver's ability to metabolize and the kidney's ability to excrete.\r\n\r\nWhen caring for a client with cirrhosis, how does this condition impact the dosages prescribed for the client?\r\n\r\nNote: Answers to these can be found in the \"Answer Key<\/a>\" sections at the end of the book.\r\n\r\n<\/div>\r\n<\/div>\r\n\r\nDid you know the power of grapefruit juice?<\/h1>\r\nA Juicy Story<\/strong>[footnote]\"Grapefruit<\/a>\" by ExplorerBob<\/a> is licensed under CC0<\/a>[\/footnote]![\"Photo](\"https:\/\/opentextbc.ca\/accessibilitytoolkit\/wp-content\/uploads\/sites\/397\/2022\/05\/image8.png\" "\\"\"Grapefruit\"")
\r\n<\/strong>\r\n\r\nDid you know that, in some people, a single glass of grapefruit juice can alter levels of drugs used to treat allergies, heart diseases, and infections? Fifteen years ago, pharmacologists discovered this \"grapefruit juice effect\" by luck, after giving volunteers grapefruit juice to mask the taste of a medicine. Nearly a decade later, researchers figured out that grapefruit juice affects the metabolizing rates of some medicines by lowering levels of a drug-metabolizing enzyme, called CYP3A4 (part of the CYP450 family of drug-binding enzymes), in the intestines. <\/span>\r\n\r\nMore recently, Paul B. Watkins of the University of North Carolina at Chapel Hill discovered that other juices like Seville (sour) orange juice\u2014but not regular orange juice\u2014have the same effect on the liver's ability to metabolize using enzymes. Each of ten people who volunteered for Watkins' juice-medicine study took a standard dose of felodopine (Plendil), a drug used to treat high blood pressure, diluted in grapefruit juice, sour orange juice, or plain orange juice. The researchers measured blood levels of\u00a0 Plendil at various times afterward. The team observed that both grapefruit juice and sour orange juice increased blood levels of Plendil, as if the people had received a higher dose. Regular orange juice had no effect. Watkins and his coworkers have found that a chemical common to grapefruit and sour oranges, dihydroxybergamottin, is likely the molecular culprit.\u00a0 Thus, when taking medications that use the CYP3A4 enzyme to metabolize, clients are advised to avoid grapefruit juice and sour orange juice.<\/span>\r\n\r\n<\/div>\r\nAttributions<\/h3>\r\n\r\n \t- The first three paragraphs of the chapter and \"Did you know the power of grapefruit juice?\" were adapted from Medicines by Design<\/em><\/a> by Allison Davis (US Department of Health and Human Services) and is in the public domain.<\/li>\r\n<\/ul>","rendered":"
![\"Image](\"https:\/\/opentextbc.ca\/accessibilitytoolkit\/wp-content\/uploads\/sites\/397\/2019\/09\/image6-300x300.png\" "\\"'Liver")
Figure 1.5 Liver<\/figcaption><\/figure>\nOnce a drug has been absorbed and distributed in the body, it will then be broken down by a process known as metabolism<\/a>. The breakdown of a drug molecule usually involves two steps that take place primarily in the body’s chemical processing plant: the liver. See Figure 1.5[1]<\/sup><\/a> for an image of a human liver. Everything that enters the bloodstream\u2014whether swallowed, injected, inhaled, absorbed through the skin, or produced by the body itself\u2014is carried to this largest internal organ.<\/p>\nThe biotransformations that take place in the liver are performed by the liver enzymes. Every one of your cells has a variety of enzymes, and each enzyme specializes in a particular job. Some enzymes break molecules apart, while others link small molecules into long chains. With drugs, the first step in metabolizing occurs through a process known as the first-pass effect<\/a>, in which orally administered drugs are broken down in the liver and intestines.\u00a0 This makes the substance easier to excrete in the urine. Medications made of protein that are swallowed or otherwise absorbed in the GI tract may quickly be deactivated by enzymes as they pass through the stomach and duodenum. If the drug enters the blood from the intestines, part of it will be broken down by liver enzymes, known as the first-pass effect, and some of it will escape to the general circulation to either be protein-bound (inactive) or stay free (and create an action at a receptor site). Thus, several doses of an oral medication may be needed to maintain enough active free drug in the circulation to exert the desired effect.<\/p>\nMany of the products of enzymatic breakdown, which are called metabolites, are less chemically active than the original molecule. For this reason, scientists refer to the liver as a “detoxifying” organ.\u00a0 \u00a0However, rather than being destroyed by liver enzymes, a few drugs are metabolized into an active form of an intended drug called a “prodrug.”\u00a0 Prodrugs have chemical activities of their own\u2014sometimes as powerful as those of the original drug. When prescribing certain drugs, healthcare providers must take into account these added effects. Once liver enzymes are finished working on a medicine, the now-inactive drug undergoes the final stage of its time in the body – excretion – as it exits via the urine or feces.<\/p>\n
Lifespan Considerations<\/h1>\n
Neonate & Pediatric:<\/strong> The developing liver in infants and young children produces decreased levels of microsomal enzymes. This may result in a decreased ability of the young child or neonate to metabolize medications. In contrast, older children may experience increased metabolism and require higher doses of medications once the hepatic enzymes are fully produced.[2]<\/sup><\/a><\/p>\nOlder Adult:<\/strong> Hepatic metabolism may experience a significant decline in the older adult. As a result, dosages should be adjusted according to the client’s liver function and anticipated metabolic rate. First-pass metabolism is also decreased with aging; therefore, older adults may have higher “free” circulating drug concentrations and be at higher risk for side effects and toxicities.[3]<\/sup><\/a><\/p>\n\n\nClinical Reasoning and Decision Making Activity 1.5<\/p>\n<\/header>\n
\nMetabolism can be influenced by many factors within the body. If a client has liver damage, the client may not be able to break down (metabolize) medications as efficiently. Dosages are calculated according to the liver’s ability to metabolize and the kidney’s ability to excrete.<\/p>\n
When caring for a client with cirrhosis, how does this condition impact the dosages prescribed for the client?<\/p>\n
Note: Answers to these can be found in the “Answer Key<\/a>” sections at the end of the book.<\/p>\n<\/div>\n<\/div>\n\nDid you know the power of grapefruit juice?<\/h1>\n
A Juicy Story<\/strong>[4]<\/sup><\/a>
\n<\/strong><\/p>\nDid you know that, in some people, a single glass of grapefruit juice can alter levels of drugs used to treat allergies, heart diseases, and infections? Fifteen years ago, pharmacologists discovered this “grapefruit juice effect” by luck, after giving volunteers grapefruit juice to mask the taste of a medicine. Nearly a decade later, researchers figured out that grapefruit juice affects the metabolizing rates of some medicines by lowering levels of a drug-metabolizing enzyme, called CYP3A4 (part of the CYP450 family of drug-binding enzymes), in the intestines. <\/span><\/p>\nMore recently, Paul B. Watkins of the University of North Carolina at Chapel Hill discovered that other juices like Seville (sour) orange juice\u2014but not regular orange juice\u2014have the same effect on the liver’s ability to metabolize using enzymes. Each of ten people who volunteered for Watkins’ juice-medicine study took a standard dose of felodopine (Plendil), a drug used to treat high blood pressure, diluted in grapefruit juice, sour orange juice, or plain orange juice. The researchers measured blood levels of\u00a0 Plendil at various times afterward. The team observed that both grapefruit juice and sour orange juice increased blood levels of Plendil, as if the people had received a higher dose. Regular orange juice had no effect. Watkins and his coworkers have found that a chemical common to grapefruit and sour oranges, dihydroxybergamottin, is likely the molecular culprit.\u00a0 Thus, when taking medications that use the CYP3A4 enzyme to metabolize, clients are advised to avoid grapefruit juice and sour orange juice.<\/span><\/p>\n<\/div>\nAttributions<\/h3>\n\n- The first three paragraphs of the chapter and “Did you know the power of grapefruit juice?” were adapted from Medicines by Design<\/em><\/a> by Allison Davis (US Department of Health and Human Services) and is in the public domain.<\/li>\n<\/ul>\n
- 'Liver Hepatic Organ Jaundice Bile Fatty Liver - Liver<\/a>' by VSRao<\/a> is licensed under CC0<\/a> ↵<\/a><\/li>
- Fernandez, E., Perez, R., Hernandez, A., Tejada, P., Arteta, M., & Ramos, J. T. (2011). Factors and mechanisms for pharmacokinetic differences between pediatric population and adults. Pharmaceutics, 3(1), 53\u201372. https:\/\/doi.org\/10.3390\/pharmaceutics3010053<\/a> ↵<\/a><\/li>
- Fernandez, E., Perez, R., Hernandez, A., Tejada, P., Arteta, M., & Ramos, J. T. (2011). Factors and mechanisms for pharmacokinetic differences between pediatric population and adults. Pharmaceutics, 3(1), 53\u201372. https:\/\/doi.org\/10.3390\/pharmaceutics3010053<\/a> ↵<\/a><\/li>
- \"Grapefruit<\/a>\" by ExplorerBob<\/a> is licensed under CC0<\/a> ↵<\/a><\/li><\/ol><\/div>definition<\/span>
The breakdown of a drug molecule via enzymes in the liver (primarily) or intestines (secondarily).<\/p>\n<\/div>
Clinical Reasoning and Decision Making Activity 1.5<\/p>\r\n\r\n<\/header>\r\n
Metabolism can be influenced by many factors within the body. If a client has liver damage, the client may not be able to break down (metabolize) medications as efficiently. Dosages are calculated according to the liver's ability to metabolize and the kidney's ability to excrete.\r\n\r\nWhen caring for a client with cirrhosis, how does this condition impact the dosages prescribed for the client?\r\n\r\nNote: Answers to these can be found in the \"Answer Key<\/a>\" sections at the end of the book.\r\n\r\n<\/div>\r\n<\/div>\r\nDid you know the power of grapefruit juice?<\/h1>\r\nA Juicy Story<\/strong>[footnote]\"Grapefruit<\/a>\" by ExplorerBob<\/a> is licensed under CC0<\/a>[\/footnote]\r\n<\/strong>\r\n\r\nDid you know that, in some people, a single glass of grapefruit juice can alter levels of drugs used to treat allergies, heart diseases, and infections? Fifteen years ago, pharmacologists discovered this \"grapefruit juice effect\" by luck, after giving volunteers grapefruit juice to mask the taste of a medicine. Nearly a decade later, researchers figured out that grapefruit juice affects the metabolizing rates of some medicines by lowering levels of a drug-metabolizing enzyme, called CYP3A4 (part of the CYP450 family of drug-binding enzymes), in the intestines. <\/span>\r\n\r\nMore recently, Paul B. Watkins of the University of North Carolina at Chapel Hill discovered that other juices like Seville (sour) orange juice\u2014but not regular orange juice\u2014have the same effect on the liver's ability to metabolize using enzymes. Each of ten people who volunteered for Watkins' juice-medicine study took a standard dose of felodopine (Plendil), a drug used to treat high blood pressure, diluted in grapefruit juice, sour orange juice, or plain orange juice. The researchers measured blood levels of\u00a0 Plendil at various times afterward. The team observed that both grapefruit juice and sour orange juice increased blood levels of Plendil, as if the people had received a higher dose. Regular orange juice had no effect. Watkins and his coworkers have found that a chemical common to grapefruit and sour oranges, dihydroxybergamottin, is likely the molecular culprit.\u00a0 Thus, when taking medications that use the CYP3A4 enzyme to metabolize, clients are advised to avoid grapefruit juice and sour orange juice.<\/span>\r\n\r\n<\/div>\r\nAttributions<\/h3>\r\n\r\n \t- The first three paragraphs of the chapter and \"Did you know the power of grapefruit juice?\" were adapted from Medicines by Design<\/em><\/a> by Allison Davis (US Department of Health and Human Services) and is in the public domain.<\/li>\r\n<\/ul>","rendered":"
Figure 1.5 Liver<\/figcaption><\/figure>\nOnce a drug has been absorbed and distributed in the body, it will then be broken down by a process known as metabolism<\/a>. The breakdown of a drug molecule usually involves two steps that take place primarily in the body’s chemical processing plant: the liver. See Figure 1.5[1]<\/sup><\/a> for an image of a human liver. Everything that enters the bloodstream\u2014whether swallowed, injected, inhaled, absorbed through the skin, or produced by the body itself\u2014is carried to this largest internal organ.<\/p>\nThe biotransformations that take place in the liver are performed by the liver enzymes. Every one of your cells has a variety of enzymes, and each enzyme specializes in a particular job. Some enzymes break molecules apart, while others link small molecules into long chains. With drugs, the first step in metabolizing occurs through a process known as the first-pass effect<\/a>, in which orally administered drugs are broken down in the liver and intestines.\u00a0 This makes the substance easier to excrete in the urine. Medications made of protein that are swallowed or otherwise absorbed in the GI tract may quickly be deactivated by enzymes as they pass through the stomach and duodenum. If the drug enters the blood from the intestines, part of it will be broken down by liver enzymes, known as the first-pass effect, and some of it will escape to the general circulation to either be protein-bound (inactive) or stay free (and create an action at a receptor site). Thus, several doses of an oral medication may be needed to maintain enough active free drug in the circulation to exert the desired effect.<\/p>\nMany of the products of enzymatic breakdown, which are called metabolites, are less chemically active than the original molecule. For this reason, scientists refer to the liver as a “detoxifying” organ.\u00a0 \u00a0However, rather than being destroyed by liver enzymes, a few drugs are metabolized into an active form of an intended drug called a “prodrug.”\u00a0 Prodrugs have chemical activities of their own\u2014sometimes as powerful as those of the original drug. When prescribing certain drugs, healthcare providers must take into account these added effects. Once liver enzymes are finished working on a medicine, the now-inactive drug undergoes the final stage of its time in the body – excretion – as it exits via the urine or feces.<\/p>\n
Lifespan Considerations<\/h1>\n
Neonate & Pediatric:<\/strong> The developing liver in infants and young children produces decreased levels of microsomal enzymes. This may result in a decreased ability of the young child or neonate to metabolize medications. In contrast, older children may experience increased metabolism and require higher doses of medications once the hepatic enzymes are fully produced.[2]<\/sup><\/a><\/p>\nOlder Adult:<\/strong> Hepatic metabolism may experience a significant decline in the older adult. As a result, dosages should be adjusted according to the client’s liver function and anticipated metabolic rate. First-pass metabolism is also decreased with aging; therefore, older adults may have higher “free” circulating drug concentrations and be at higher risk for side effects and toxicities.[3]<\/sup><\/a><\/p>\n\n\nClinical Reasoning and Decision Making Activity 1.5<\/p>\n<\/header>\n
\nMetabolism can be influenced by many factors within the body. If a client has liver damage, the client may not be able to break down (metabolize) medications as efficiently. Dosages are calculated according to the liver’s ability to metabolize and the kidney’s ability to excrete.<\/p>\n
When caring for a client with cirrhosis, how does this condition impact the dosages prescribed for the client?<\/p>\n
Note: Answers to these can be found in the “Answer Key<\/a>” sections at the end of the book.<\/p>\n<\/div>\n<\/div>\n\nDid you know the power of grapefruit juice?<\/h1>\n
A Juicy Story<\/strong>[4]<\/sup><\/a>
\n<\/strong><\/p>\nDid you know that, in some people, a single glass of grapefruit juice can alter levels of drugs used to treat allergies, heart diseases, and infections? Fifteen years ago, pharmacologists discovered this “grapefruit juice effect” by luck, after giving volunteers grapefruit juice to mask the taste of a medicine. Nearly a decade later, researchers figured out that grapefruit juice affects the metabolizing rates of some medicines by lowering levels of a drug-metabolizing enzyme, called CYP3A4 (part of the CYP450 family of drug-binding enzymes), in the intestines. <\/span><\/p>\nMore recently, Paul B. Watkins of the University of North Carolina at Chapel Hill discovered that other juices like Seville (sour) orange juice\u2014but not regular orange juice\u2014have the same effect on the liver’s ability to metabolize using enzymes. Each of ten people who volunteered for Watkins’ juice-medicine study took a standard dose of felodopine (Plendil), a drug used to treat high blood pressure, diluted in grapefruit juice, sour orange juice, or plain orange juice. The researchers measured blood levels of\u00a0 Plendil at various times afterward. The team observed that both grapefruit juice and sour orange juice increased blood levels of Plendil, as if the people had received a higher dose. Regular orange juice had no effect. Watkins and his coworkers have found that a chemical common to grapefruit and sour oranges, dihydroxybergamottin, is likely the molecular culprit.\u00a0 Thus, when taking medications that use the CYP3A4 enzyme to metabolize, clients are advised to avoid grapefruit juice and sour orange juice.<\/span><\/p>\n<\/div>\nAttributions<\/h3>\n\n- The first three paragraphs of the chapter and “Did you know the power of grapefruit juice?” were adapted from Medicines by Design<\/em><\/a> by Allison Davis (US Department of Health and Human Services) and is in the public domain.<\/li>\n<\/ul>\n
- 'Liver Hepatic Organ Jaundice Bile Fatty Liver - Liver<\/a>' by VSRao<\/a> is licensed under CC0<\/a> ↵<\/a><\/li>
- Fernandez, E., Perez, R., Hernandez, A., Tejada, P., Arteta, M., & Ramos, J. T. (2011). Factors and mechanisms for pharmacokinetic differences between pediatric population and adults. Pharmaceutics, 3(1), 53\u201372. https:\/\/doi.org\/10.3390\/pharmaceutics3010053<\/a> ↵<\/a><\/li>
- Fernandez, E., Perez, R., Hernandez, A., Tejada, P., Arteta, M., & Ramos, J. T. (2011). Factors and mechanisms for pharmacokinetic differences between pediatric population and adults. Pharmaceutics, 3(1), 53\u201372. https:\/\/doi.org\/10.3390\/pharmaceutics3010053<\/a> ↵<\/a><\/li>
- \"Grapefruit<\/a>\" by ExplorerBob<\/a> is licensed under CC0<\/a> ↵<\/a><\/li><\/ol><\/div>definition<\/span>
The breakdown of a drug molecule via enzymes in the liver (primarily) or intestines (secondarily).<\/p>\n<\/div>
- \r\n \t
- The first three paragraphs of the chapter and \"Did you know the power of grapefruit juice?\" were adapted from Medicines by Design<\/em><\/a> by Allison Davis (US Department of Health and Human Services) and is in the public domain.<\/li>\r\n<\/ul>","rendered":"
Figure 1.5 Liver<\/figcaption><\/figure>\n Once a drug has been absorbed and distributed in the body, it will then be broken down by a process known as metabolism<\/a>. The breakdown of a drug molecule usually involves two steps that take place primarily in the body’s chemical processing plant: the liver. See Figure 1.5[1]<\/sup><\/a> for an image of a human liver. Everything that enters the bloodstream\u2014whether swallowed, injected, inhaled, absorbed through the skin, or produced by the body itself\u2014is carried to this largest internal organ.<\/p>\n
The biotransformations that take place in the liver are performed by the liver enzymes. Every one of your cells has a variety of enzymes, and each enzyme specializes in a particular job. Some enzymes break molecules apart, while others link small molecules into long chains. With drugs, the first step in metabolizing occurs through a process known as the first-pass effect<\/a>, in which orally administered drugs are broken down in the liver and intestines.\u00a0 This makes the substance easier to excrete in the urine. Medications made of protein that are swallowed or otherwise absorbed in the GI tract may quickly be deactivated by enzymes as they pass through the stomach and duodenum. If the drug enters the blood from the intestines, part of it will be broken down by liver enzymes, known as the first-pass effect, and some of it will escape to the general circulation to either be protein-bound (inactive) or stay free (and create an action at a receptor site). Thus, several doses of an oral medication may be needed to maintain enough active free drug in the circulation to exert the desired effect.<\/p>\n
Many of the products of enzymatic breakdown, which are called metabolites, are less chemically active than the original molecule. For this reason, scientists refer to the liver as a “detoxifying” organ.\u00a0 \u00a0However, rather than being destroyed by liver enzymes, a few drugs are metabolized into an active form of an intended drug called a “prodrug.”\u00a0 Prodrugs have chemical activities of their own\u2014sometimes as powerful as those of the original drug. When prescribing certain drugs, healthcare providers must take into account these added effects. Once liver enzymes are finished working on a medicine, the now-inactive drug undergoes the final stage of its time in the body – excretion – as it exits via the urine or feces.<\/p>\n
Lifespan Considerations<\/h1>\n
Neonate & Pediatric:<\/strong> The developing liver in infants and young children produces decreased levels of microsomal enzymes. This may result in a decreased ability of the young child or neonate to metabolize medications. In contrast, older children may experience increased metabolism and require higher doses of medications once the hepatic enzymes are fully produced.[2]<\/sup><\/a><\/p>\n
Older Adult:<\/strong> Hepatic metabolism may experience a significant decline in the older adult. As a result, dosages should be adjusted according to the client’s liver function and anticipated metabolic rate. First-pass metabolism is also decreased with aging; therefore, older adults may have higher “free” circulating drug concentrations and be at higher risk for side effects and toxicities.[3]<\/sup><\/a><\/p>\n
\n\n Clinical Reasoning and Decision Making Activity 1.5<\/p>\n<\/header>\n
\nMetabolism can be influenced by many factors within the body. If a client has liver damage, the client may not be able to break down (metabolize) medications as efficiently. Dosages are calculated according to the liver’s ability to metabolize and the kidney’s ability to excrete.<\/p>\nWhen caring for a client with cirrhosis, how does this condition impact the dosages prescribed for the client?<\/p>\n
Note: Answers to these can be found in the “Answer Key<\/a>” sections at the end of the book.<\/p>\n<\/div>\n<\/div>\n
\nDid you know the power of grapefruit juice?<\/h1>\n
A Juicy Story<\/strong>[4]<\/sup><\/a>
\n<\/strong><\/p>\nDid you know that, in some people, a single glass of grapefruit juice can alter levels of drugs used to treat allergies, heart diseases, and infections? Fifteen years ago, pharmacologists discovered this “grapefruit juice effect” by luck, after giving volunteers grapefruit juice to mask the taste of a medicine. Nearly a decade later, researchers figured out that grapefruit juice affects the metabolizing rates of some medicines by lowering levels of a drug-metabolizing enzyme, called CYP3A4 (part of the CYP450 family of drug-binding enzymes), in the intestines. <\/span><\/p>\n
More recently, Paul B. Watkins of the University of North Carolina at Chapel Hill discovered that other juices like Seville (sour) orange juice\u2014but not regular orange juice\u2014have the same effect on the liver’s ability to metabolize using enzymes. Each of ten people who volunteered for Watkins’ juice-medicine study took a standard dose of felodopine (Plendil), a drug used to treat high blood pressure, diluted in grapefruit juice, sour orange juice, or plain orange juice. The researchers measured blood levels of\u00a0 Plendil at various times afterward. The team observed that both grapefruit juice and sour orange juice increased blood levels of Plendil, as if the people had received a higher dose. Regular orange juice had no effect. Watkins and his coworkers have found that a chemical common to grapefruit and sour oranges, dihydroxybergamottin, is likely the molecular culprit.\u00a0 Thus, when taking medications that use the CYP3A4 enzyme to metabolize, clients are advised to avoid grapefruit juice and sour orange juice.<\/span><\/p>\n<\/div>\n
Attributions<\/h3>\n
- \n
- The first three paragraphs of the chapter and “Did you know the power of grapefruit juice?” were adapted from Medicines by Design<\/em><\/a> by Allison Davis (US Department of Health and Human Services) and is in the public domain.<\/li>\n<\/ul>\n
- 'Liver Hepatic Organ Jaundice Bile Fatty Liver - Liver<\/a>' by VSRao<\/a> is licensed under CC0<\/a> ↵<\/a><\/li>
- Fernandez, E., Perez, R., Hernandez, A., Tejada, P., Arteta, M., & Ramos, J. T. (2011). Factors and mechanisms for pharmacokinetic differences between pediatric population and adults. Pharmaceutics, 3(1), 53\u201372. https:\/\/doi.org\/10.3390\/pharmaceutics3010053<\/a> ↵<\/a><\/li>
- Fernandez, E., Perez, R., Hernandez, A., Tejada, P., Arteta, M., & Ramos, J. T. (2011). Factors and mechanisms for pharmacokinetic differences between pediatric population and adults. Pharmaceutics, 3(1), 53\u201372. https:\/\/doi.org\/10.3390\/pharmaceutics3010053<\/a> ↵<\/a><\/li>
- \"Grapefruit<\/a>\" by ExplorerBob<\/a> is licensed under CC0<\/a> ↵<\/a><\/li><\/ol><\/div>
definition<\/span>The breakdown of a drug molecule via enzymes in the liver (primarily) or intestines (secondarily).<\/p>\n<\/div>
- Fernandez, E., Perez, R., Hernandez, A., Tejada, P., Arteta, M., & Ramos, J. T. (2011). Factors and mechanisms for pharmacokinetic differences between pediatric population and adults. Pharmaceutics, 3(1), 53\u201372. https:\/\/doi.org\/10.3390\/pharmaceutics3010053<\/a> ↵<\/a><\/li>
- 'Liver Hepatic Organ Jaundice Bile Fatty Liver - Liver<\/a>' by VSRao<\/a> is licensed under CC0<\/a> ↵<\/a><\/li>
- The first three paragraphs of the chapter and “Did you know the power of grapefruit juice?” were adapted from Medicines by Design<\/em><\/a> by Allison Davis (US Department of Health and Human Services) and is in the public domain.<\/li>\n<\/ul>\n